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Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
[Image: see text] Tankyrases 1 and 2 are central biotargets in the WNT/β-catenin signaling and Hippo signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole moiety and binding predominantly to the adenosine binding site of the tankyrase catalytic domain. Here w...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008393/ https://www.ncbi.nlm.nih.gov/pubmed/32511917 http://dx.doi.org/10.1021/acs.jmedchem.0c00208 |