Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC Catalysis

The recent surge in applications of deuterated pharmaceutical agents has created an urgent demand for synthetic methods that efficiently generate deuterated building blocks. Here we show that N-heterocyclic carbenes (NHC) promote a reversible hydrogen-deuterium exchange (HDE) reaction with simple al...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Huihui, Chen, Xiaobei, Gui, Jingjing, Zhang, Yueteng, Shen, Zuyuan, Qian, Pengfei, Chen, Junwei, Zhang, Shilei, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008838/
https://www.ncbi.nlm.nih.gov/pubmed/33791590
http://dx.doi.org/10.1038/s41929-019-0370-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008838/
https://www.ncbi.nlm.nih.gov/pubmed/33791590
http://dx.doi.org/10.1038/s41929-019-0370-z

Ejemplares similares