DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria

The mycobacterial cell wall glycolipid trehalose-6,6-dimycolate (TDM) activates macrophages through the C-type lectin receptor MINCLE. Regulation of innate immune cells relies on miRNAs, which may be exploited by mycobacteria to survive and replicate in macrophages. Here, we have used macrophages de...

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Detalles Bibliográficos
Autores principales: Killy, Barbara, Bodendorfer, Barbara, Mages, Jörg, Ritter, Kristina, Schreiber, Jonathan, Hölscher, Christoph, Pracht, Katharina, Ekici, Arif, Jäck, Hans-Martin, Lang, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008949/
https://www.ncbi.nlm.nih.gov/pubmed/33771876
http://dx.doi.org/10.26508/lsa.202000810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008949/
https://www.ncbi.nlm.nih.gov/pubmed/33771876
http://dx.doi.org/10.26508/lsa.202000810

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