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A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing
Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism. Chemical-induced gene expression profile provides a mechanistic signature of phenotypic response. However, the use of such data is limited by their sparseness,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009091/ https://www.ncbi.nlm.nih.gov/pubmed/33796820 http://dx.doi.org/10.1038/s42256-020-00285-9 |