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A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing

Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism. Chemical-induced gene expression profile provides a mechanistic signature of phenotypic response. However, the use of such data is limited by their sparseness,...

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Detalles Bibliográficos
Autores principales: Pham, Thai-Hoang, Qiu, Yue, Zeng, Jucheng, Xie, Lei, Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009091/
https://www.ncbi.nlm.nih.gov/pubmed/33796820
http://dx.doi.org/10.1038/s42256-020-00285-9