Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography

[Image: see text] The main protease (3CL M(pro)) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is an essential enzyme for viral replication with no human counterpart, making it an attractive drug target. To date, no small-molecule clinical drugs a...

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Detalles Bibliográficos
Autores principales: Kneller, Daniel W., Phillips, Gwyndalyn, Weiss, Kevin L., Zhang, Qiu, Coates, Leighton, Kovalevsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009097/
https://www.ncbi.nlm.nih.gov/pubmed/33755450
http://dx.doi.org/10.1021/acs.jmedchem.1c00058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009097/
https://www.ncbi.nlm.nih.gov/pubmed/33755450
http://dx.doi.org/10.1021/acs.jmedchem.1c00058

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