Cargando…
Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which anti-citrullinated protein antibodies (ACPA) are most prominent. ACPA are produced by citrullinated antigen-binding B cells that have presuma...
Autores principales: | Slot, Linda M., Vergroesen, Rochelle D., Kerkman, Priscilla F., Staudinger, Ellen, Reijm, Sanne, van Dooren, Hugo J., van der Voort, Ellen I. H., Huizinga, Tom W. J., Toes, René E. M., Scherer, Hans U. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009422/ https://www.ncbi.nlm.nih.gov/pubmed/33784344 http://dx.doi.org/10.1371/journal.pone.0247847 |
Ejemplares similares
-
N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development
por: Vergroesen, Rochelle D., et al.
Publicado: (2019) -
Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis
por: Kroos, Sanne, et al.
Publicado: (2022) -
Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3(+) memory B cells and plasmablasts
por: Reijm, Sanne, et al.
Publicado: (2023) -
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
por: Kissel, Theresa, et al.
Publicado: (2022) -
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCP) affects severity of rheumatoid arthritis
por: van Gaalen, FA, et al.
Publicado: (2004)