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Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that th...

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Detalles Bibliográficos
Autores principales: Plummer, Jason D, Postnikoff, Spike DL, Tyler, Jessica K, Johnson, Jay E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009673/
https://www.ncbi.nlm.nih.gov/pubmed/33783357
http://dx.doi.org/10.7554/eLife.62483