Cargando…
Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that th...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009673/ https://www.ncbi.nlm.nih.gov/pubmed/33783357 http://dx.doi.org/10.7554/eLife.62483 |
_version_ | 1783672923049951232 |
---|---|
author | Plummer, Jason D Postnikoff, Spike DL Tyler, Jessica K Johnson, Jay E |
author_facet | Plummer, Jason D Postnikoff, Spike DL Tyler, Jessica K Johnson, Jay E |
author_sort | Plummer, Jason D |
collection | PubMed |
description | Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Selenomethionine supplementation results in a similar, albeit less robust response, and also extends budding yeast lifespan. Our results indicate that selenium supplementation is sufficient to produce MR-like healthspan benefits for yeast and mammals. |
format | Online Article Text |
id | pubmed-8009673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-80096732021-03-31 Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice Plummer, Jason D Postnikoff, Spike DL Tyler, Jessica K Johnson, Jay E eLife Biochemistry and Chemical Biology Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Selenomethionine supplementation results in a similar, albeit less robust response, and also extends budding yeast lifespan. Our results indicate that selenium supplementation is sufficient to produce MR-like healthspan benefits for yeast and mammals. eLife Sciences Publications, Ltd 2021-03-30 /pmc/articles/PMC8009673/ /pubmed/33783357 http://dx.doi.org/10.7554/eLife.62483 Text en © 2021, Plummer et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Biochemistry and Chemical Biology Plummer, Jason D Postnikoff, Spike DL Tyler, Jessica K Johnson, Jay E Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title_full | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title_fullStr | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title_full_unstemmed | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title_short | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
title_sort | selenium supplementation inhibits igf-1 signaling and confers methionine restriction-like healthspan benefits to mice |
topic | Biochemistry and Chemical Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009673/ https://www.ncbi.nlm.nih.gov/pubmed/33783357 http://dx.doi.org/10.7554/eLife.62483 |
work_keys_str_mv | AT plummerjasond seleniumsupplementationinhibitsigf1signalingandconfersmethioninerestrictionlikehealthspanbenefitstomice AT postnikoffspikedl seleniumsupplementationinhibitsigf1signalingandconfersmethioninerestrictionlikehealthspanbenefitstomice AT tylerjessicak seleniumsupplementationinhibitsigf1signalingandconfersmethioninerestrictionlikehealthspanbenefitstomice AT johnsonjaye seleniumsupplementationinhibitsigf1signalingandconfersmethioninerestrictionlikehealthspanbenefitstomice |