Cargando…

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibitor, decreased glucocorticoid-induced ocular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Guorong, Lee, Chanyoung, Read, A Thomas, Wang, Ke, Ha, Jungmin, Kuhn, Megan, Navarro, Iris, Cui, Jenny, Young, Katherine, Gorijavolu, Rahul, Sulchek, Todd, Kopczynski, Casey, Farsiu, Sina, Samples, John, Challa, Pratap, Ethier, C Ross, Stamer, W Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009676/ https://www.ncbi.nlm.nih.gov/pubmed/33783352 http://dx.doi.org/10.7554/eLife.60831

Ejemplares similares

The relationship between outflow resistance and trabecular meshwork stiffness in mice
por: Wang, Ke, et al.
Publicado: (2018)

Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms
por: Ren, Ruiyi, et al.
Publicado: (2016)

In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model
por: Li, Guorong, et al.
Publicado: (2019)

Trabodenoson, an Adenosine Mimetic With A(1) Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice
por: Li, Guorong, et al.
Publicado: (2018)

VEGF as a Paracrine Regulator of Conventional Outflow Facility
por: Reina-Torres, Ester, et al.
Publicado: (2017)

Thrombospondin‐1 mediates Rho‐kinase inhibitor‐induced increase in outflow‐facility
por: Shan, Sze‐Wan, et al.
Publicado: (2021)

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes
por: Ren, Ruiyi, et al.
Publicado: (2023)

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
por: Li, Guorong, et al.
Publicado: (2020)

Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (Tupaia belangeri)
por: Jasien, Jessica V., et al.
Publicado: (2022)

sCD44 overexpression increases intraocular pressure and aqueous outflow resistance
por: Giovingo, Michael, et al.
Publicado: (2013)

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration
por: Wen, Joanne C., et al.
Publicado: (2017)

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia
por: De Ieso, Michael L., et al.
Publicado: (2020)

Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography
por: Li, Guorong, et al.
Publicado: (2014)

Phase 3 Clinical Trial Comparing the Safety and Efficacy of Netarsudil to Ripasudil in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: Japan Rho Kinase Elevated Intraocular Pressure Treatment Trial (J-ROCKET)
por: Araie, Makoto, et al.
Publicado: (2023)

A model of the oscillatory mechanical forces in the conventional outflow pathway
por: Sherwood, Joseph M., et al.
Publicado: (2019)

Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes
por: Strohmaier, Clemens A., et al.
Publicado: (2023)

Age and Menopause Effects on Ocular Compliance and Aqueous Outflow
por: Feola, Andrew J., et al.
Publicado: (2020)

Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a
por: Luna, Coralia, et al.
Publicado: (2021)

Dose-dependent effects of netarsudil, a Rho-kinase inhibitor, on the distal outflow tract
por: Chen, Si, et al.
Publicado: (2020)

Therapeutic ultrasound for glaucoma: clinical use of a low-frequency low-power ultrasound device for lowering intraocular pressure
por: Schwartz, Donald, et al.
Publicado: (2014)

Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm’s Canal Endothelia
por: Tam, Lawrence C. S., et al.
Publicado: (2017)

The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway
por: Karimi, Alireza, et al.
Publicado: (2022)

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
por: Ge, Pei, et al.
Publicado: (2016)

The role of Piezo1 in conventional aqueous humor outflow dynamics
por: Zhu, Wei, et al.
Publicado: (2021)

Autotaxin-Lysophosphatidic Acid Axis Is a Novel Molecular Target for Lowering Intraocular Pressure
por: Iyer, Padma, et al.
Publicado: (2012)

Transgene expression of Stanniocalcin-1 provides sustained intraocular pressure reduction by increasing outflow facility
por: Roddy, Gavin W., et al.
Publicado: (2022)

Fibrotic Changes to Schlemm’s Canal Endothelial Cells in Glaucoma
por: Kelly, Ruth A., et al.
Publicado: (2021)

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye
por: Ryskamp, Daniel A., et al.
Publicado: (2016)

Protective Effects of Resveratrol in Experimental Retinal Detachment
por: Huang, Wei, et al.
Publicado: (2013)

Acute effects of posture on intraocular pressure
por: Nelson, Emily S., et al.
Publicado: (2020)

The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity
por: Rackow, Ashley R., et al.
Publicado: (2022)

Acute Effects of Intraocular Pressure-Induced Changes in Schlemm's Canal Morphology on Outflow Facility in Healthy Human Eyes
por: Chen, Wei, et al.
Publicado: (2020)

SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes
por: Ashwinbalaji, Soundararajan, et al.
Publicado: (2018)

TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma
por: Hill, Lisa J., et al.
Publicado: (2018)

RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells
por: Liu, Zhicheng, et al.
Publicado: (2021)

Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway
por: Soundararajan, Avinash, et al.
Publicado: (2021)

TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor
por: Torrejon, Karen Y., et al.
Publicado: (2016)

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics
por: Patel, Gaurang, et al.
Publicado: (2020)

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
por: McDowell, Colleen M., et al.
Publicado: (2022)

Substance P induces fibrotic changes through activation of the RhoA/ROCK pathway in an in vitro human corneal fibrosis model
por: Słoniecka, Marta, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qv3p81qbbghd3gc702t1c3pdha