Cargando…
Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate
Acid-sensing ion channels (ASICs) are neuronal Na(+) channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them promising targets for future drugs. Currently, t...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009679/ https://www.ncbi.nlm.nih.gov/pubmed/33729158 http://dx.doi.org/10.7554/eLife.66488 |