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Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

Acid-sensing ion channels (ASICs) are neuronal Na(+) channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them promising targets for future drugs. Currently, t...

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Detalles Bibliográficos
Autores principales:	Vullo, Sabrina, Ambrosio, Nicolas, Kucera, Jan P, Bignucolo, Olivier, Kellenberger, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009679/ https://www.ncbi.nlm.nih.gov/pubmed/33729158 http://dx.doi.org/10.7554/eLife.66488

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