Notum deacylates octanoylated ghrelin

OBJECTIVES: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Schuhmacher, Laura-Nadine, Roberts, Morgan, Kakugawa, Satoshi, Bineva-Todd, Ganka, Howell, Steve, O'Reilly, Nicola, Perret, Christine, Snijders, Ambrosius P., Vincent, Jean-Paul, Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010218/
https://www.ncbi.nlm.nih.gov/pubmed/33647468
http://dx.doi.org/10.1016/j.molmet.2021.101201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010218/
https://www.ncbi.nlm.nih.gov/pubmed/33647468
http://dx.doi.org/10.1016/j.molmet.2021.101201

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