The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DRLyp/Lyp Rats

The depleting Vβ13a T cell receptor monoclonal antibody (mAb) 17D5 prevents both induced and spontaneous autoimmune diabetes in BB rats. Here it was tested in congenic DRLyp/Lyp rats, all of which spontaneously developed diabetes. Starting at 40 days of age, rats were injected once weekly with eithe...

Descripción completa

Detalles Bibliográficos
Autores principales: Bogdani, Marika, Faxius, Linda, Fex, Malin, Ramelius, Anita, Wernersson, Anya, Mordes, John P., Blankenhorn, Elizabeth P., Lernmark, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010654/
https://www.ncbi.nlm.nih.gov/pubmed/33815287
http://dx.doi.org/10.3389/fendo.2021.629242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010654/
https://www.ncbi.nlm.nih.gov/pubmed/33815287
http://dx.doi.org/10.3389/fendo.2021.629242

Ejemplares similares