Cargando…

Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial–Mesenchymal Transition-Like Response During Ventricle Regeneration

Unlike mammals, zebrafish can regenerate injured hearts even in the adult stage. Cardiac regeneration requires the coordination of cardiomyocyte (CM) proliferation and migration. The TGF-β/Smad3 signaling pathway has been implicated in cardiac regeneration, but the molecular mechanisms by which this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Yuanyuan, Wang, Wenyuan, Fang, Yunzheng, Hu, Haichen, Chang, Nannan, Pang, Meijun, Hu, Ye-Fan, Li, Xueyu, Long, Han, Xiong, Jing-Wei, Zhang, Ruilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010688/ https://www.ncbi.nlm.nih.gov/pubmed/33816481 http://dx.doi.org/10.3389/fcell.2021.632372

Ejemplares similares

Corrigendum: Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial–Mesenchymal Transition-Like Response During Ventricle Regeneration
por: Peng, Yuanyuan, et al.
Publicado: (2021)

BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration
por: Wang, Wenyuan, et al.
Publicado: (2021)

Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration
por: Geng, Fang, et al.
Publicado: (2021)

Manipulating Cardiomyocyte Plasticity for Heart Regeneration
por: Ko, Toshiyuki, et al.
Publicado: (2022)

The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration
por: Bo, Bing, et al.
Publicado: (2021)

Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration
por: Zhao, Ming-Tao, et al.
Publicado: (2020)

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2019)

Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration
por: Sharpe, Michka, et al.
Publicado: (2022)

Corrigendum: Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2020)

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
por: Meng, Ke, et al.
Publicado: (2021)

Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function
por: Xu, Rui, et al.
Publicado: (2021)

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
por: Meng, Ke, et al.
Publicado: (2023)

Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion
por: Fang, Yabo, et al.
Publicado: (2020)

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
por: Ge, Jun, et al.
Publicado: (2020)

β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway
por: Yan, Cai-Ping, et al.
Publicado: (2022)

Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling
por: Deng, Jiamin, et al.
Publicado: (2021)

A Functional SMAD2/3 Binding Site in the PEX11β Promoter Identifies a Role for TGFβ in Peroxisome Proliferation in Humans
por: Azadi, Afsoon S., et al.
Publicado: (2020)

Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish
por: Gemberling, Matthew, et al.
Publicado: (2015)

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells
por: Katkat, Esra, et al.
Publicado: (2023)

Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration
por: Paris, Nicole D, et al.
Publicado: (2016)

Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control
por: Xin, Ting, et al.
Publicado: (2020)

Naturally Engineered Maturation of Cardiomyocytes
por: Scuderi, Gaetano J., et al.
Publicado: (2017)

Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling
por: Bai, Jian, et al.
Publicado: (2021)

Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice
por: Cao, Tongtong, et al.
Publicado: (2019)

Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover
por: Richardson, Gavin D.
Publicado: (2016)

Cardiomyocyte-fibroblast crosstalk in the postnatal heart
por: Uscategui Calderon, Maria, et al.
Publicado: (2023)

Intermittent Starvation Promotes Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes
por: Yang, Jingsi, et al.
Publicado: (2021)

The Role of SMAD2/3 in Human Embryonic Stem Cells
por: Yang, Jie, et al.
Publicado: (2020)

Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases
por: Li, Anqi, et al.
Publicado: (2020)

Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes
por: Liao, Hongyu, et al.
Publicado: (2021)

Sympathetic Neurons Regulate Cardiomyocyte Maturation in Culture
por: Kowalski, William J., et al.
Publicado: (2022)

Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis
por: Li, Cao, et al.
Publicado: (2020)

Disruption of LTBP4 Inhibition-Induced TGFβ1 Activation Promoted Cell Proliferation and Metastasis in Skin Melanoma by Inhibiting the Activation of the Hippo-YAP1 Signaling Pathway
por: Wang, Lina, et al.
Publicado: (2022)

Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity
por: Ma, Wanjun, et al.
Publicado: (2020)

Editorial: Cardiomyocyte Maturation: Novel Insights for Regenerative Medicine
por: Zhang, Min, et al.
Publicado: (2021)

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation
por: Yücel, Dogacan, et al.
Publicado: (2022)

Cardiomyocyte cohesion is increased after ADAM17 inhibition
por: Shoykhet, Maria, et al.
Publicado: (2023)

Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish
por: Tang, Weiyi, et al.
Publicado: (2019)

TGFβ1 in Cancer-Associated Fibroblasts Is Associated With Progression and Radiosensitivity in Small-Cell Lung Cancer
por: Zhang, Jiaqi, et al.
Publicado: (2021)

The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration
por: Zhu, Sipin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lga9qneenpdbvkvm0n67cjshtn