Mutational and biophysical robustness in a prestabilized monobody

The fibronectin type III (FN3) monobody domain is a promising non-antibody scaffold, which features a less complex architecture than an antibody while maintaining analogous binding loops. We previously developed FN3Con, a hyperstable monobody derivative with diagnostic and therapeutic potential. Pre...

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Detalles Bibliográficos
Autores principales: Chandler, Peter G., Tan, Li Lynn, Porebski, Benjamin T., Green, James S., Riley, Blake T., Broendum, Sebastian S., Hoke, David E., Falconer, Robert J., Munro, Trent P., Buckle, Malcolm, Jackson, Colin J., Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010708/
https://www.ncbi.nlm.nih.gov/pubmed/33617878
http://dx.doi.org/10.1016/j.jbc.2021.100447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010708/
https://www.ncbi.nlm.nih.gov/pubmed/33617878
http://dx.doi.org/10.1016/j.jbc.2021.100447

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