Alternative splicing of OAS1 alters the risk for severe COVID-19

A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ~75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occur...

Descripción completa

Detalles Bibliográficos
Autores principales: Huffman, Jennifer, Butler-Laporte, Guillaume, Khan, Atlas, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Verma, Anurag, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010745/
https://www.ncbi.nlm.nih.gov/pubmed/33791713
http://dx.doi.org/10.1101/2021.03.20.21254005
_version_ 1783673118739398656
author Huffman, Jennifer
Butler-Laporte, Guillaume
Khan, Atlas
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Verma, Anurag
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
author_facet Huffman, Jennifer
Butler-Laporte, Guillaume
Khan, Atlas
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Verma, Anurag
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
author_sort Huffman, Jennifer
collection PubMed
description A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ~75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.
format Online
Article
Text
id pubmed-8010745
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-80107452021-04-01 Alternative splicing of OAS1 alters the risk for severe COVID-19 Huffman, Jennifer Butler-Laporte, Guillaume Khan, Atlas Drivas, Theodore G. Peloso, Gina M. Nakanishi, Tomoko Verma, Anurag Kiryluk, Krzysztof Richards, J. Brent Zeberg, Hugo medRxiv Article A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ~75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry. Cold Spring Harbor Laboratory 2021-03-25 /pmc/articles/PMC8010745/ /pubmed/33791713 http://dx.doi.org/10.1101/2021.03.20.21254005 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Huffman, Jennifer
Butler-Laporte, Guillaume
Khan, Atlas
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Verma, Anurag
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
Alternative splicing of OAS1 alters the risk for severe COVID-19
title Alternative splicing of OAS1 alters the risk for severe COVID-19
title_full Alternative splicing of OAS1 alters the risk for severe COVID-19
title_fullStr Alternative splicing of OAS1 alters the risk for severe COVID-19
title_full_unstemmed Alternative splicing of OAS1 alters the risk for severe COVID-19
title_short Alternative splicing of OAS1 alters the risk for severe COVID-19
title_sort alternative splicing of oas1 alters the risk for severe covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010745/
https://www.ncbi.nlm.nih.gov/pubmed/33791713
http://dx.doi.org/10.1101/2021.03.20.21254005
work_keys_str_mv AT huffmanjennifer alternativesplicingofoas1alterstheriskforseverecovid19
AT butlerlaporteguillaume alternativesplicingofoas1alterstheriskforseverecovid19
AT khanatlas alternativesplicingofoas1alterstheriskforseverecovid19
AT drivastheodoreg alternativesplicingofoas1alterstheriskforseverecovid19
AT pelosoginam alternativesplicingofoas1alterstheriskforseverecovid19
AT nakanishitomoko alternativesplicingofoas1alterstheriskforseverecovid19
AT vermaanurag alternativesplicingofoas1alterstheriskforseverecovid19
AT kirylukkrzysztof alternativesplicingofoas1alterstheriskforseverecovid19
AT richardsjbrent alternativesplicingofoas1alterstheriskforseverecovid19
AT zeberghugo alternativesplicingofoas1alterstheriskforseverecovid19

Ejemplares similares