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The haplolethality paradox of the wupA gene in Drosophila
Haplolethals (HL) are regions of diploid genomes that in one dose are fatal for the organism. Their biological meaning is obscure because heterozygous loss-of-function mutations result in dominant lethality (DL) and, consequently, should be under strong negative selection. We report an in depth stud...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011728/ https://www.ncbi.nlm.nih.gov/pubmed/33739971 http://dx.doi.org/10.1371/journal.pgen.1009108 |