Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

Huntington disease (HD) damages the corticostriatal circuitry in large part by impairing transport of brain-derived neurotrophic factor (BDNF). We hypothesized that improving vesicular transport of BDNF could slow or prevent disease progression. We therefore performed selective proteomic analysis of...

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Detalles Bibliográficos
Autores principales: Virlogeux, Amandine, Scaramuzzino, Chiara, Lenoir, Sophie, Carpentier, Rémi, Louessard, Morgane, Genoux, Aurélie, Lino, Patricia, Hinckelmann, Maria-Victoria, Perrier, Anselme L., Humbert, Sandrine, Saudou, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011966/
https://www.ncbi.nlm.nih.gov/pubmed/33789888
http://dx.doi.org/10.1126/sciadv.abb0799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011966/
https://www.ncbi.nlm.nih.gov/pubmed/33789888
http://dx.doi.org/10.1126/sciadv.abb0799

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