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Processed foods drive intestinal barrier permeability and microvascular diseases

Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an incr...

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Autores principales: Snelson, Matthew, Tan, Sih Min, Clarke, Rachel E., de Pasquale, Cassandra, Thallas-Bonke, Vicki, Nguyen, Tuong-Vi, Penfold, Sally A., Harcourt, Brooke E., Sourris, Karly C., Lindblom, Runa S., Ziemann, Mark, Steer, David, El-Osta, Assam, Davies, Michael J., Donnellan, Leigh, Deo, Permal, Kellow, Nicole J., Cooper, Mark E., Woodruff, Trent M., Mackay, Charles R., Forbes, Josephine M., Coughlan, Melinda T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011970/
https://www.ncbi.nlm.nih.gov/pubmed/33789895
http://dx.doi.org/10.1126/sciadv.abe4841
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author Snelson, Matthew
Tan, Sih Min
Clarke, Rachel E.
de Pasquale, Cassandra
Thallas-Bonke, Vicki
Nguyen, Tuong-Vi
Penfold, Sally A.
Harcourt, Brooke E.
Sourris, Karly C.
Lindblom, Runa S.
Ziemann, Mark
Steer, David
El-Osta, Assam
Davies, Michael J.
Donnellan, Leigh
Deo, Permal
Kellow, Nicole J.
Cooper, Mark E.
Woodruff, Trent M.
Mackay, Charles R.
Forbes, Josephine M.
Coughlan, Melinda T.
author_facet Snelson, Matthew
Tan, Sih Min
Clarke, Rachel E.
de Pasquale, Cassandra
Thallas-Bonke, Vicki
Nguyen, Tuong-Vi
Penfold, Sally A.
Harcourt, Brooke E.
Sourris, Karly C.
Lindblom, Runa S.
Ziemann, Mark
Steer, David
El-Osta, Assam
Davies, Michael J.
Donnellan, Leigh
Deo, Permal
Kellow, Nicole J.
Cooper, Mark E.
Woodruff, Trent M.
Mackay, Charles R.
Forbes, Josephine M.
Coughlan, Melinda T.
author_sort Snelson, Matthew
collection PubMed
description Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease.
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spelling pubmed-80119702021-04-13 Processed foods drive intestinal barrier permeability and microvascular diseases Snelson, Matthew Tan, Sih Min Clarke, Rachel E. de Pasquale, Cassandra Thallas-Bonke, Vicki Nguyen, Tuong-Vi Penfold, Sally A. Harcourt, Brooke E. Sourris, Karly C. Lindblom, Runa S. Ziemann, Mark Steer, David El-Osta, Assam Davies, Michael J. Donnellan, Leigh Deo, Permal Kellow, Nicole J. Cooper, Mark E. Woodruff, Trent M. Mackay, Charles R. Forbes, Josephine M. Coughlan, Melinda T. Sci Adv Research Articles Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease. American Association for the Advancement of Science 2021-03-31 /pmc/articles/PMC8011970/ /pubmed/33789895 http://dx.doi.org/10.1126/sciadv.abe4841 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Snelson, Matthew
Tan, Sih Min
Clarke, Rachel E.
de Pasquale, Cassandra
Thallas-Bonke, Vicki
Nguyen, Tuong-Vi
Penfold, Sally A.
Harcourt, Brooke E.
Sourris, Karly C.
Lindblom, Runa S.
Ziemann, Mark
Steer, David
El-Osta, Assam
Davies, Michael J.
Donnellan, Leigh
Deo, Permal
Kellow, Nicole J.
Cooper, Mark E.
Woodruff, Trent M.
Mackay, Charles R.
Forbes, Josephine M.
Coughlan, Melinda T.
Processed foods drive intestinal barrier permeability and microvascular diseases
title Processed foods drive intestinal barrier permeability and microvascular diseases
title_full Processed foods drive intestinal barrier permeability and microvascular diseases
title_fullStr Processed foods drive intestinal barrier permeability and microvascular diseases
title_full_unstemmed Processed foods drive intestinal barrier permeability and microvascular diseases
title_short Processed foods drive intestinal barrier permeability and microvascular diseases
title_sort processed foods drive intestinal barrier permeability and microvascular diseases
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011970/
https://www.ncbi.nlm.nih.gov/pubmed/33789895
http://dx.doi.org/10.1126/sciadv.abe4841
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