Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca(2+)-dependent priming

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca(2+)-sensors for vesicle fusion in mouse chromaffin cel...

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Detalles Bibliográficos
Autores principales: Tawfik, Bassam, Martins, Joana S, Houy, Sébastien, Imig, Cordelia, Pinheiro, Paulo S, Wojcik, Sonja M, Brose, Nils, Cooper, Benjamin H, Sørensen, Jakob Balslev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012061/
https://www.ncbi.nlm.nih.gov/pubmed/33749593
http://dx.doi.org/10.7554/eLife.64527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012061/
https://www.ncbi.nlm.nih.gov/pubmed/33749593
http://dx.doi.org/10.7554/eLife.64527

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