Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity

Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO) constantly leads to lipid accretion in liver. However, much less is known about the mechanism(s) of drug-induced steatosis in the absence of s...

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Detalles Bibliográficos
Autores principales: Allard, Julien, Bucher, Simon, Massart, Julie, Ferron, Pierre-Jean, Le Guillou, Dounia, Loyant, Roxane, Daniel, Yoann, Launay, Youenn, Buron, Nelly, Begriche, Karima, Borgne-Sanchez, Annie, Fromenty, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012331/
https://www.ncbi.nlm.nih.gov/pubmed/32535746
http://dx.doi.org/10.1007/s10565-020-09537-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012331/
https://www.ncbi.nlm.nih.gov/pubmed/32535746
http://dx.doi.org/10.1007/s10565-020-09537-1

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