Low Diversity of Human Variation Despite Mostly Mild Functional Impact of De Novo Variants

Non-synonymous Single Nucleotide Variants (nsSNVs), resulting in single amino acid variants (SAVs), are important drivers of evolutionary adaptation across the tree of life. Humans carry on average over 10,000 SAVs per individual genome, many of which likely have little to no impact on the function...

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Detalles Bibliográficos
Autores principales: Mahlich, Yannick, Miller, Maximillian, Zeng, Zishuo, Bromberg, Yana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012514/
https://www.ncbi.nlm.nih.gov/pubmed/33816556
http://dx.doi.org/10.3389/fmolb.2021.635382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012514/
https://www.ncbi.nlm.nih.gov/pubmed/33816556
http://dx.doi.org/10.3389/fmolb.2021.635382

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