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Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using the high-throughput SEquencing-Based Yeast replicative Lifespan screen method and the yeast knockout collection, we demonstrate that the HDA complex, a cl...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012573/ https://www.ncbi.nlm.nih.gov/pubmed/33790287 http://dx.doi.org/10.1038/s41467-021-22257-2 |