Cargando…

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using the high-throughput SEquencing-Based Yeast replicative Lifespan screen method and the yeast knockout collection, we demonstrate that the HDA complex, a cl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Ruofan, Cao, Xiaohua, Sun, Luyang, Zhu, Jun-yi, Wasko, Brian M, Liu, Wei, Crutcher, Emeline, Liu, Haiying, Jo, Myeong Chan, Qin, Lidong, Kaeberlein, Matt, Han, Zhe, Dang, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012573/ https://www.ncbi.nlm.nih.gov/pubmed/33790287 http://dx.doi.org/10.1038/s41467-021-22257-2

Ejemplares similares

HIGH THROUGHPUT YEAST REPLICATIVE LIFESPAN SCREEN UNCOVERS HISTONE DEACETYLASE HDA AS NOVEL REGULATOR OF AGING
por: Yu, Ruofan, et al.
Publicado: (2019)

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
por: Shao, Li-Wa, et al.
Publicado: (2020)

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans
por: Emerson, Felicity J., et al.
Publicado: (2023)

Involvement of Arabidopsis histone deacetylase HDA6 in ABA and salt stress response
por: Chen, Li-Ting, et al.
Publicado: (2010)

Histone Deacetylase HDA6 Is Functionally Associated with AS1 in Repression of KNOX Genes in Arabidopsis
por: Luo, Ming, et al.
Publicado: (2012)

Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans
por: Kawamura, Kazuto, et al.
Publicado: (2020)

Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans
por: Higashitani, Atsushi, et al.
Publicado: (2021)

Cellular response to moderate chromatin architectural defects promotes longevity
por: Yu, Ruofan, et al.
Publicado: (2019)

HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis
por: Zacchi, Lucia F., et al.
Publicado: (2010)

The tomato histone deacetylase SlHDA1 contributes to the repression of fruit ripening and carotenoid accumulation
por: Guo, Jun-E, et al.
Publicado: (2017)

A Histone Deacetylase, MoHDA1 Regulates Asexual Development and Virulence in the Rice Blast Fungus
por: Kim, Taehyun, et al.
Publicado: (2020)

The Histone Deacetylases HosA and HdaA Affect the Phenotype and Transcriptomic and Metabolic Profiles of Aspergillus niger
por: Li, Xuejie, et al.
Publicado: (2019)

Histone Deacetylase HDA9 With ABI4 Contributes to Abscisic Acid Homeostasis in Drought Stress Response
por: Baek, Dongwon, et al.
Publicado: (2020)

The Hda1 histone deacetylase limits divergent non‐coding transcription and restricts transcription initiation frequency
por: Gowthaman, Uthra, et al.
Publicado: (2021)

Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae
por: Shen, Hui, et al.
Publicado: (2016)

Phylogenetic analysis, subcellular localization, and expression patterns of RPD3/HDA1 family histone deacetylases in plants
por: Alinsug, Malona V, et al.
Publicado: (2009)

The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4
por: Nikooei, Tatiana, et al.
Publicado: (2020)

Histone deacetylase MdHDA6 is an antagonist in regulation of transcription factor MdTCP15 to promote cold tolerance in apple
por: Guo, Meimiao, et al.
Publicado: (2023)

Longevity and aging
por: Kaeberlein, Matt
Publicado: (2013)

The histone deacetylase HDA19 controls root cell elongation and modulates a subset of phosphate starvation responses in Arabidopsis
por: Chen, Chun-Ying, et al.
Publicado: (2015)

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
por: Ortega, Pedro, et al.
Publicado: (2019)

Defining molecular basis for longevity traits in natural yeast isolates
por: Kaya, Alaattin, et al.
Publicado: (2015)

Induction of Secondary Metabolite Biosynthesis by Deleting the Histone Deacetylase HdaA in the Marine-Derived Fungus Aspergillus terreus RA2905
por: Zheng, Yao-Yao, et al.
Publicado: (2022)

Histone Deacetylase HDA15 Restrains PHYB-Dependent Seed Germination via Directly Repressing GA20ox1/2 Gene Expression
por: Zheng, Feng, et al.
Publicado: (2022)

Companion dogs to test longevity interventions
por: Kaeberlein, Matt
Publicado: (2020)

Caenorhabditis elegans Histone Deacetylase hda-1 Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates
por: Ranawade, Ayush Vasant, et al.
Publicado: (2013)

Ethylene response factor MdERF4 and histone deacetylase MdHDA19 suppress apple fruit ripening through histone deacetylation of ripening-related genes
por: Hu, Yanan, et al.
Publicado: (2022)

Involvement of histone deacetylase CsHDA2 in regulating (E)-nerolidol formation in tea (Camellia sinensis) exposed to tea green leafhopper infestation
por: Gu, Dachuan, et al.
Publicado: (2022)

Transcription activator WCC recruits deacetylase HDA3 to control transcription dynamics and bursting in Neurospora
por: Oehler, Michael, et al.
Publicado: (2023)

HDA6-dependent histone deacetylation regulates mRNA polyadenylation in Arabidopsis
por: Lin, Juncheng, et al.
Publicado: (2020)

Histone Deacetylase TaHDT701 Functions in TaHDA6-TaHOS15 Complex to Regulate Wheat Defense Responses to Blumeria graminis f.sp. tritici
por: Zhi, Pengfei, et al.
Publicado: (2020)

RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity
por: Frankel, Stewart, et al.
Publicado: (2015)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

MdMADS6 Recruits Histone Deacetylase MdHDA19 to Repress the Expression of the Carotenoid Synthesis-Related Gene MdCCD1 during Fruit Ripening
por: Li, Qiqi, et al.
Publicado: (2022)

Histone H4-Specific Deacetylation at Active Coding Regions by Hda1C
por: Lee, Min Kyung, et al.
Publicado: (2020)

H3K36 methylation promotes longevity by enhancing transcriptional fidelity
por: Sen, Payel, et al.
Publicado: (2015)

The yeast Cyc8–Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene
por: Fleming, Alastair B., et al.
Publicado: (2014)

FLAVIN-CONTAINING MONOOXYGENASES (FMOS): LONGEVITY-PROMOTING ENZYMES OR ATHEROSCLEROSIS RISK FACTOR?
por: Rossner, Ryan J, et al.
Publicado: (2019)

Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans
por: Yanos, Melana E, et al.
Publicado: (2012)

LONGEVITY OVER THE COUNTER: INVESTIGATING THE EFFECTS OF COMMON DIETARY SUPPLEMENTS ON AGING
por: Blue, Ben, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fvijqr4teejrttalrrrd4rkhi3