Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD). In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2. These transporters are inhibited by some hypouricemic agents; OATs by probenecid and benzbromarone, ABCG2 by febuxostat and benzbromarone. Thus,...

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Detalles Bibliográficos
Autores principales: Taniguchi, Tetsuya, Omura, Koichi, Motoki, Keisuke, Sakai, Miku, Chikamatsu, Noriko, Ashizawa, Naoki, Takada, Tappei, Iwanaga, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012596/
https://www.ncbi.nlm.nih.gov/pubmed/33790363
http://dx.doi.org/10.1038/s41598-021-86662-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012596/
https://www.ncbi.nlm.nih.gov/pubmed/33790363
http://dx.doi.org/10.1038/s41598-021-86662-9

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