Cargando…

Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD). In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2. These transporters are inhibited by some hypouricemic agents; OATs by probenecid and benzbromarone, ABCG2 by febuxostat and benzbromarone. Thus,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taniguchi, Tetsuya, Omura, Koichi, Motoki, Keisuke, Sakai, Miku, Chikamatsu, Noriko, Ashizawa, Naoki, Takada, Tappei, Iwanaga, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012596/ https://www.ncbi.nlm.nih.gov/pubmed/33790363 http://dx.doi.org/10.1038/s41598-021-86662-9

Ejemplares similares

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
por: Takada, T., et al.
Publicado: (2018)

Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9
por: Yong, Tianqiao, et al.
Publicado: (2018)

ABCG5 and ABCG8 Are Involved in Vitamin K Transport
por: Matsuo, Michinori, et al.
Publicado: (2023)

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
por: Miyata, Sachiho, et al.
Publicado: (2021)

Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2
por: Matsuo, Hirotaka, et al.
Publicado: (2016)

Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate
por: Matsuo, Koji, et al.
Publicado: (2015)

The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study
por: King, Jasia, et al.
Publicado: (2021)

Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway
por: Nakano, Takehiro, et al.
Publicado: (2021)

Indoxyl Sulfate, a Uremic Endotheliotoxin
por: Lano, Guillaume, et al.
Publicado: (2020)

Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells
por: Ng, Hwee-Yeong, et al.
Publicado: (2014)

Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function
por: Matsumoto, Takayuki, et al.
Publicado: (2020)

Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies
por: Leong, Sheldon C., et al.
Publicado: (2016)

Indoxyl sulfate impairs valsartan-induced neovascularization()
por: Kuo, Ko-Lin, et al.
Publicado: (2020)

Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis
por: Shyu, Jia-Fwu, et al.
Publicado: (2021)

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications
por: Toyoda, Yu, et al.
Publicado: (2019)

Hypouricemic Effects of Extracts from Urtica hyperborea Jacq. ex Wedd. in Hyperuricemia Mice through XOD, URAT1, and OAT1
por: Han, Surina, et al.
Publicado: (2020)

p-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis
por: Hyun, Hye Sun, et al.
Publicado: (2013)

Acute Exposure to Indoxyl Sulfate Impairs Endothelium-Dependent Vasorelaxation in Rat Aorta
por: Matsumoto, Takayuki, et al.
Publicado: (2019)

Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
por: Kim, Young-Hee, et al.
Publicado: (2013)

Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
por: Devine, Eric, et al.
Publicado: (2014)

Indoxyl sulfate in uremia: an old idea with updated concepts
por: Berg, Anders H., et al.
Publicado: (2022)

Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate
por: Pieniazek, Anna, et al.
Publicado: (2022)

Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
por: Ahmed, Mohamed Siyabeldin E, et al.
Publicado: (2013)

Prognostic Utility of Indoxyl Sulfate for Patients with Acute Coronary Syndrome
por: Watanabe, Ippei, et al.
Publicado: (2019)

Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model
por: Karbowska, Malgorzata, et al.
Publicado: (2020)

Indoxyl Sulfate and Incident Peripheral Artery Disease in Hemodialysis Patients
por: Lin, Ting-Yun, et al.
Publicado: (2020)

Indoxyl-Sulfate-Induced Redox Imbalance in Chronic Kidney Disease
por: Lu, Chien-Lin, et al.
Publicado: (2021)

Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate
por: Opdebeeck, Britt, et al.
Publicado: (2020)

The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients
por: Wu, Ping-Hsun, et al.
Publicado: (2021)

Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages
por: Barisione, Chiara, et al.
Publicado: (2016)

The role of indoxyl sulfate in renal anemia in patients with chronic kidney disease
por: Wu, Chih-Jen, et al.
Publicado: (2017)

AST-120 Reduces Neuroinflammation Induced by Indoxyl Sulfate in Glial Cells
por: Adesso, Simona, et al.
Publicado: (2018)

Indoxyl sulfate is associated with mortality after AKI – more evidence needed!
por: Menez, Steven, et al.
Publicado: (2019)

Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy
por: Sun, Chiao-Yin, et al.
Publicado: (2021)

Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations
por: Miyata, Hiroshi, et al.
Publicado: (2016)

Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate
por: Nakagawa, Keisuke, et al.
Publicado: (2022)

The fecal microbiome and serum concentrations of indoxyl sulfate and p‐cresol sulfate in cats with chronic kidney disease
por: Summers, Stacie C., et al.
Publicado: (2018)

Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120
por: Liu, Wen-Chih, et al.
Publicado: (2018)

Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients
por: Lin, Cheng-Jui, et al.
Publicado: (2017)

Familial early-onset hyperuricemia and gout associated with a newly identified dysfunctional variant in urate transporter ABCG2
por: Toyoda, Yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_db4pmi6foncj3bimtmhfn7hna5