Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

Lipid carriers of hydrophobic paclitaxel (PTX) are used in clinical trials for cancer chemotherapy. Improving their loading capacity requires enhanced PTX solubilization. We compared the time-dependence of PTX membrane solubility as a function of PTX content in cationic liposomes (CLs) with lipid ta...

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Detalles Bibliográficos
Autores principales: Zhen, Yuhong, Ewert, Kai K., Fisher, William S., Steffes, Victoria M., Li, Youli, Safinya, Cyrus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012651/
https://www.ncbi.nlm.nih.gov/pubmed/33790325
http://dx.doi.org/10.1038/s41598-021-86484-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012651/
https://www.ncbi.nlm.nih.gov/pubmed/33790325
http://dx.doi.org/10.1038/s41598-021-86484-9

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