Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity

The neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational modifications impinge on spectrin, the major component of the MPS, but their role remains poorly understood. One modification targeting spectrin is...

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Detalles Bibliográficos
Autores principales: Miazek, Arkadiusz, Zalas, Michał, Skrzymowska, Joanna, Bogin, Bryan A., Grzymajło, Krzysztof, Goszczynski, Tomasz M., Levine, Zachary A., Morrow, Jon S., Stankewich, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012654/
https://www.ncbi.nlm.nih.gov/pubmed/33790315
http://dx.doi.org/10.1038/s41598-021-86470-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012654/
https://www.ncbi.nlm.nih.gov/pubmed/33790315
http://dx.doi.org/10.1038/s41598-021-86470-1

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