Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle

Exercise prevents depression through peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α)-mediated activation of a particular branch of the kynurenine pathway. From kynurenine (KYN), two independent metabolic pathways produce neurofunctionally different metabolites, mainly in som...

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Detalles Bibliográficos
Autores principales: Fang, Chongye, Hayashi, Shuhei, Du, Xiaocui, Cai, Xianbin, Deng, Bin, Zheng, Hongmei, Ishido, Satoshi, Tsutsui, Hiroko, Sheng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012704/
https://www.ncbi.nlm.nih.gov/pubmed/33790369
http://dx.doi.org/10.1038/s41598-021-86659-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012704/
https://www.ncbi.nlm.nih.gov/pubmed/33790369
http://dx.doi.org/10.1038/s41598-021-86659-4

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