Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal cell loss. Recently, dysregulation of intracellular Ca(2+) homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Here, we investigated (1) the pathogenic role of destabiliz...

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Detalles Bibliográficos
Autores principales: Nakamura, Yoshihide, Yamamoto, Takeshi, Xu, Xiaojuan, Kobayashi, Shigeki, Tanaka, Shinji, Tamitani, Masaki, Saito, Takashi, Saido, Takaomi C., Yano, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012710/
https://www.ncbi.nlm.nih.gov/pubmed/33790404
http://dx.doi.org/10.1038/s41598-021-86822-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012710/
https://www.ncbi.nlm.nih.gov/pubmed/33790404
http://dx.doi.org/10.1038/s41598-021-86822-x

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