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Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal cell loss. Recently, dysregulation of intracellular Ca(2+) homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Here, we investigated (1) the pathogenic role of destabiliz...
Autores principales: | Nakamura, Yoshihide, Yamamoto, Takeshi, Xu, Xiaojuan, Kobayashi, Shigeki, Tanaka, Shinji, Tamitani, Masaki, Saito, Takashi, Saido, Takaomi C., Yano, Masafumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012710/ https://www.ncbi.nlm.nih.gov/pubmed/33790404 http://dx.doi.org/10.1038/s41598-021-86822-x |
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