Cargando…
COVID‐19 patients often show high‐titer non‐platelet‐activating anti‐PF4/heparin IgG antibodies
BACKGROUND: Heparin‐induced thrombocytopenia (HIT) is a severe adverse reaction to heparin caused by heparin‐dependent, platelet‐activating anti‐platelet factor 4 (PF4)/heparin antibodies. Heparin is a cornerstone of treatment in critically ill COVID‐19 patients. HIT antibodies can be detected by an...
Autores principales: | Brodard, Justine, Kremer Hovinga, Johanna A., Fontana, Pierre, Studt, Jan‐Dirk, Gruel, Yves, Greinacher, Andreas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Journal of Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013750/ https://www.ncbi.nlm.nih.gov/pubmed/33550713 http://dx.doi.org/10.1111/jth.15262 |
Ejemplares similares
-
Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy
por: Greinacher, Andreas, et al.
Publicado: (2021) -
The Deglycosylated Form of 1E12, a Monoclonal Anti-PF4 IgG, Strongly Inhibits Antibody-Triggered Cellular Activation in Vaccine-Induced Thrombotic Thrombocytopenia, and Is a Potential New Treatment for Vιττ
por: Vayne, Caroline, et al.
Publicado: (2021) -
The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia
por: Draxler, Dominik F., et al.
Publicado: (2022) -
Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia
por: Giles, Jason B., et al.
Publicado: (2022) -
Alternative diagnosis to heparin-induced thrombocytopenia in two critically ill patients despite a positive PF4/heparin-antibody test
por: Hron, Gregor, et al.
Publicado: (2013)