Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum

Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington’s disease (HD). In neurons, mutant Huntingtin collects in aggregates and distributes to the same sites as wild-type Huntingtin including on membranes and in synapses....

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Detalles Bibliográficos
Autores principales: Iuliano, Maria, Seeley, Connor, Sapp, Ellen, Jones, Erin L., Martin, Callie, Li, Xueyi, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013775/
https://www.ncbi.nlm.nih.gov/pubmed/33815086
http://dx.doi.org/10.3389/fnsyn.2021.618391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013775/
https://www.ncbi.nlm.nih.gov/pubmed/33815086
http://dx.doi.org/10.3389/fnsyn.2021.618391

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