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E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new modality of chemical tools and potential therapeutics to understand and treat human disease. A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another lig...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013866/ https://www.ncbi.nlm.nih.gov/pubmed/33143537 http://dx.doi.org/10.1177/2472555220965528 |