Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes

[Image: see text] An atom- and step-economical strategy for the synthesis of bisphosphinoylaminomethanes is reported. This metal-free bisphosphinylation reaction proceeded smoothly through a base-mediated direct 1,1-bisphosphonation of phosphine oxides and isocyanides under mild conditions. The pres...

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Autores principales: Yuan, Qing, Liu, Hua-Wei, Cai, Zhong-Jian, Ji, Shun-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015124/
https://www.ncbi.nlm.nih.gov/pubmed/33817511
http://dx.doi.org/10.1021/acsomega.1c00160
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author Yuan, Qing
Liu, Hua-Wei
Cai, Zhong-Jian
Ji, Shun-Jun
author_facet Yuan, Qing
Liu, Hua-Wei
Cai, Zhong-Jian
Ji, Shun-Jun
author_sort Yuan, Qing
collection PubMed
description [Image: see text] An atom- and step-economical strategy for the synthesis of bisphosphinoylaminomethanes is reported. This metal-free bisphosphinylation reaction proceeded smoothly through a base-mediated direct 1,1-bisphosphonation of phosphine oxides and isocyanides under mild conditions. The present method offers a facile, efficient, and general approach to a broad range of bisphosphinoylaminomethane derivatives in moderate to good yields.
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spelling pubmed-80151242021-04-02 Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes Yuan, Qing Liu, Hua-Wei Cai, Zhong-Jian Ji, Shun-Jun ACS Omega [Image: see text] An atom- and step-economical strategy for the synthesis of bisphosphinoylaminomethanes is reported. This metal-free bisphosphinylation reaction proceeded smoothly through a base-mediated direct 1,1-bisphosphonation of phosphine oxides and isocyanides under mild conditions. The present method offers a facile, efficient, and general approach to a broad range of bisphosphinoylaminomethane derivatives in moderate to good yields. American Chemical Society 2021-03-17 /pmc/articles/PMC8015124/ /pubmed/33817511 http://dx.doi.org/10.1021/acsomega.1c00160 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yuan, Qing
Liu, Hua-Wei
Cai, Zhong-Jian
Ji, Shun-Jun
Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title_full Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title_fullStr Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title_full_unstemmed Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title_short Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes
title_sort direct 1,1-bisphosphonation of isocyanides: atom- and step-economical access to bisphosphinoylaminomethanes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015124/
https://www.ncbi.nlm.nih.gov/pubmed/33817511
http://dx.doi.org/10.1021/acsomega.1c00160
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