Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation

In addition to fatty acids, glucose and lactate are important myocardial substrates under physiological and stress conditions. They are metabolized to pyruvate that enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle (CAC) metabolism. Here, we show that MPC-mediate...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Taufalele, Paul V, Cochran, Jesse D, Frayne, Isabelle Robillard, Marx, Jonas Maximilian, Soto, Jamie, Rauckhorst, Adam J, Tayyari, Fariba, Pewa, Alvin D, Gray, Lawrence R, Teesch, Lynn M, Puchalska, Patrycja, Funari, Trevor R., McGlauflin, Rose, Zimmerman, Kathy, Kutschke, William J., Cassier, Thomas, Hitchcock, Shannon, Lin, Kevin, Kato, Kevin M., Stueve, Jennifer L., Haff, Lauren, Weiss, Robert M., Cox, James E., Rutter, Jared, Taylor, Eric B., Crawford, Peter A., Lewandowski, E. Douglas, Des Rosiers, Christine, Abel, E. Dale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015649/
https://www.ncbi.nlm.nih.gov/pubmed/33106689
http://dx.doi.org/10.1038/s42255-020-00288-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015649/
https://www.ncbi.nlm.nih.gov/pubmed/33106689
http://dx.doi.org/10.1038/s42255-020-00288-1

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