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Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions
While changes in MeCP2 dosage cause Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), its transcriptional regulation is poorly understood. Here, we identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Upon deletion in mice and human iPSC-deriv...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015713/ https://www.ncbi.nlm.nih.gov/pubmed/33737384 http://dx.doi.org/10.1101/gad.345397.120 |