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Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients
Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat m...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015815/ https://www.ncbi.nlm.nih.gov/pubmed/32767822 http://dx.doi.org/10.1111/jdi.13383 |
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author | Vergès, Bruno Rouland, Alexia Baillot‐Rudoni, Sabine Brindisi, Marie‐Claude Duvillard, Laurence Simoneau, Isabelle Legris, Pauline Petit, Jean‐Michel Bouillet, Benjamin |
author_facet | Vergès, Bruno Rouland, Alexia Baillot‐Rudoni, Sabine Brindisi, Marie‐Claude Duvillard, Laurence Simoneau, Isabelle Legris, Pauline Petit, Jean‐Michel Bouillet, Benjamin |
author_sort | Vergès, Bruno |
collection | PubMed |
description | Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m(2)), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosamine was correlated negatively with BMI and fat mass. In multivariate analysis, fructosamine was associated with HbA1c (positively) and fat mass (negatively), but not with BMI, liver fat or fat distribution. The association between fructosamine and HbA1c is significantly reduced in the most obese type 2 diabetes patients, and this is mostly driven by increased fat mass. |
format | Online Article Text |
id | pubmed-8015815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80158152021-04-02 Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients Vergès, Bruno Rouland, Alexia Baillot‐Rudoni, Sabine Brindisi, Marie‐Claude Duvillard, Laurence Simoneau, Isabelle Legris, Pauline Petit, Jean‐Michel Bouillet, Benjamin J Diabetes Investig Articles Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m(2)), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosamine was correlated negatively with BMI and fat mass. In multivariate analysis, fructosamine was associated with HbA1c (positively) and fat mass (negatively), but not with BMI, liver fat or fat distribution. The association between fructosamine and HbA1c is significantly reduced in the most obese type 2 diabetes patients, and this is mostly driven by increased fat mass. John Wiley and Sons Inc. 2020-09-17 2021-04 /pmc/articles/PMC8015815/ /pubmed/32767822 http://dx.doi.org/10.1111/jdi.13383 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Vergès, Bruno Rouland, Alexia Baillot‐Rudoni, Sabine Brindisi, Marie‐Claude Duvillard, Laurence Simoneau, Isabelle Legris, Pauline Petit, Jean‐Michel Bouillet, Benjamin Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title | Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title_full | Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title_fullStr | Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title_full_unstemmed | Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title_short | Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
title_sort | increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015815/ https://www.ncbi.nlm.nih.gov/pubmed/32767822 http://dx.doi.org/10.1111/jdi.13383 |
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