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Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in tandem with single-cell transcriptomics to track cellular transitions and heterogeneities of ∼22,000 liver cells through...

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Detalles Bibliográficos
Autores principales: Chembazhi, Ullas V., Bangru, Sushant, Hernaez, Mikel, Kalsotra, Auinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015853/
https://www.ncbi.nlm.nih.gov/pubmed/33649154
http://dx.doi.org/10.1101/gr.267013.120