Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells

P‐glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug resistance (MDR) in the treatment of cancers. Photoaffinity labeling of plasma membrane vesicles of MDR CHO B30 cells with the anthracycline [(125...

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Detalles Bibliográficos
Autores principales: Demmer, Annette, Thole, Hubert, Raida, Manfred, Tümmler, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016128/
https://www.ncbi.nlm.nih.gov/pubmed/33565718
http://dx.doi.org/10.1002/2211-5463.13112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016128/
https://www.ncbi.nlm.nih.gov/pubmed/33565718
http://dx.doi.org/10.1002/2211-5463.13112

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