Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

[Image: see text] As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (2a) and ursolic acids (3a) were coupled with vanillamine, and the resulting amides (2b and 3b, respectively) were assayed for activity on the vanilloid receptor TRPV1. Despite a structur...

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Detalles Bibliográficos
Autores principales: Vitale, Rosa Maria, Avonto, Cristina, Del Prete, Danilo, Moriello, Aniello Schiano, Amodeo, Pietro, Appendino, Giovanni, De Petrocellis, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016363/
https://www.ncbi.nlm.nih.gov/pubmed/33136399
http://dx.doi.org/10.1021/acs.jnatprod.0c00639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016363/
https://www.ncbi.nlm.nih.gov/pubmed/33136399
http://dx.doi.org/10.1021/acs.jnatprod.0c00639

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