How the Destabilization of a Reaction Intermediate Affects Enzymatic Efficiency: The Case of Human Transketolase

[Image: see text] Atomic resolution X-ray crystallography has shown that an intermediate (the X5P-ThDP adduct) of the catalytic cycle of transketolase (TK) displays a significant, putatively highly energetic, out-of-plane distortion in a sp(2) carbon adjacent to a lytic bond, suggested to lower the...

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Detalles Bibliográficos
Autores principales: Prejanò, Mario, Medina, Fabiola E., Ramos, Maria J., Russo, Nino, Fernandes, Pedro A., Marino, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016368/
https://www.ncbi.nlm.nih.gov/pubmed/33828899
http://dx.doi.org/10.1021/acscatal.9b04690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016368/
https://www.ncbi.nlm.nih.gov/pubmed/33828899
http://dx.doi.org/10.1021/acscatal.9b04690

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