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DeMaSk: a deep mutational scanning substitution matrix and its use for variant impact prediction

MOTIVATION: Accurately predicting the quantitative impact of a substitution on a protein’s molecular function would be a great aid in understanding the effects of observed genetic variants across populations. While this remains a challenging task, new approaches can leverage data from the increasing...

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Detalles Bibliográficos
Autores principales: Munro, Daniel, Singh, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016454/
https://www.ncbi.nlm.nih.gov/pubmed/33325500
http://dx.doi.org/10.1093/bioinformatics/btaa1030

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