Cargando…

The Role of Unfolded Protein Response in Human Intervertebral Disc Degeneration: Perk and IRE1-α as Two Potential Therapeutic Targets

Inflammation plays a key role in intervertebral disc degeneration (IDD). The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, whether ER stress plays an important role in IDD remains unclear. Therefore, this study is aimed at investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Tianyong, Xue, Peng, Ying, Jinwei, Cheng, Shi, Liu, Yue, Ruan, Dike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016586/ https://www.ncbi.nlm.nih.gov/pubmed/33833850 http://dx.doi.org/10.1155/2021/6492879

Ejemplares similares

Effects of Stromal Cell-Derived Factor-1α Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells
por: Ying, Jinwei, et al.
Publicado: (2019)

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications
por: Ge, Yuying, et al.
Publicado: (2022)

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration
por: Ou, Xuancheng, et al.
Publicado: (2020)

Activation of the IRE1α Arm, but not the PERK Arm, of the Unfolded Protein Response Contributes to Fumonisin B1-Induced Hepatotoxicity
por: Liu, Xiaoyi, et al.
Publicado: (2020)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

The effects of human Wharton’s jelly cell transplantation on the intervertebral disc in a canine disc degeneration model
por: Zhang, Yan, et al.
Publicado: (2015)

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK and IRE1α-mediated unfolded protein response
por: Jwa, Miri, et al.
Publicado: (2012)

Editorial: Cell-based therapeutics for intervertebral disc degeneration
por: Li, Zhen, et al.
Publicado: (2023)

Intervertebral disc degeneration—Current therapeutic options and challenges
por: Samanta, Ankita, et al.
Publicado: (2023)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Noninvasive cumulative axial load may induce intervertebral disc degeneration-A potential rabbit model
por: Bai, Xuedong, et al.
Publicado: (2017)

Bioactive lipids in intervertebral disc degeneration and its therapeutic implications
por: Das, Undurti N.
Publicado: (2019)

AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration
por: Wang, Zhen, et al.
Publicado: (2021)

Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications
por: Luo, Jieya, et al.
Publicado: (2022)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration
por: Guo, Zhu, et al.
Publicado: (2021)

Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
por: Chen, Hai‐Wei, et al.
Publicado: (2022)

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
por: Xu, Wen-Ning, et al.
Publicado: (2023)

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways
por: Feng, Chencheng, et al.
Publicado: (2016)

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration
por: Suzuki, Satoshi, et al.
Publicado: (2015)

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration
por: Wang, Dong, et al.
Publicado: (2022)

Current Knowledge and Future Therapeutic Prospects in Symptomatic Intervertebral Disc Degeneration
por: Kim, Joo Han, et al.
Publicado: (2022)

Role of Caspase Family in Intervertebral Disc Degeneration and Its Therapeutic Prospects
por: Li, Lei, et al.
Publicado: (2022)

Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration
por: Bahar, Md Entaz, et al.
Publicado: (2022)

Emerging role and therapeutic implications of p53 in intervertebral disc degeneration
por: Wang, Yidian, et al.
Publicado: (2023)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_juloolrn2no4jl1ttao7tefu3c