PAK4 suppresses motor neuron degeneration in hSOD1(G93A)‐linked amyotrophic lateral sclerosis cell and rat models

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed...

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Detalles Bibliográficos
Autores principales: Cong, Chaohua, Liang, Weiwei, Zhang, Chunting, Wang, Ying, Yang, Yueqing, Wang, Xudong, Wang, Shuyu, Huo, Di, Wang, Hongyong, Wang, Di, Feng, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016643/
https://www.ncbi.nlm.nih.gov/pubmed/33615605
http://dx.doi.org/10.1111/cpr.13003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016643/
https://www.ncbi.nlm.nih.gov/pubmed/33615605
http://dx.doi.org/10.1111/cpr.13003

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