Cargando…

PAK4 suppresses motor neuron degeneration in hSOD1(G93A)‐linked amyotrophic lateral sclerosis cell and rat models

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cong, Chaohua, Liang, Weiwei, Zhang, Chunting, Wang, Ying, Yang, Yueqing, Wang, Xudong, Wang, Shuyu, Huo, Di, Wang, Hongyong, Wang, Di, Feng, Honglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016643/ https://www.ncbi.nlm.nih.gov/pubmed/33615605 http://dx.doi.org/10.1111/cpr.13003

Ejemplares similares

Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis
por: Lee, John D, et al.
Publicado: (2013)

Effects of Ovariectomy in an hSOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
por: Yan, Lina, et al.
Publicado: (2018)

Compensatory Motor Neuron Response to Chromatolysis in the Murine hSOD1(G93A) Model of Amyotrophic Lateral Sclerosis
por: Riancho, Javier, et al.
Publicado: (2014)

SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1
por: Wang, Di, et al.
Publicado: (2022)

Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1(G93A) Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice
por: Pehar, Mariana, et al.
Publicado: (2014)

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Lee, Jia Y, et al.
Publicado: (2015)

DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1(G93A) model of amyotrophic lateral sclerosis in vivo and in vitro
por: Penndorf, Diane, et al.
Publicado: (2017)

Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1(G93A) ALS mouse model
por: Zhang, Haoyun, et al.
Publicado: (2022)

Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1(G93A) mice
por: Cai, MuDan, et al.
Publicado: (2013)

Effects of RAGE inhibition on the progression of the disease in hSOD1(G93A) ALS mice
por: Liu, Liping, et al.
Publicado: (2020)

Tempol Moderately Extends Survival in a hSOD1(G93A) ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1(G93A) Forms
por: Linares, Edlaine, et al.
Publicado: (2013)

Gamisoyo-San Ameliorates Neuroinflammation in the Spinal Cord of hSOD1(G93A) Transgenic Mice
por: Cai, MuDan, et al.
Publicado: (2018)

Microglia Morphological Changes in the Motor Cortex of hSOD1(G93A) Transgenic ALS Mice
por: Migliarini, Sara, et al.
Publicado: (2021)

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Wang, Haitao A., et al.
Publicado: (2017)

Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Koza, Lilia A., et al.
Publicado: (2020)

A Cystine-Rich Whey Supplement (Immunocal(®)) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Ross, Erika K., et al.
Publicado: (2014)

The Effects of Bee Venom Acupuncture on the Central Nervous System and Muscle in an Animal hSOD1(G93A) Mutant
por: Cai, MuDan, et al.
Publicado: (2015)

Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1(G93A) Transgenic Mice
por: Lee, Sun-Hwa, et al.
Publicado: (2015)

Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model
por: Stella, Roberto, et al.
Publicado: (2021)

Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
por: Moreno-Martinez, Laura, et al.
Publicado: (2022)

Combined Treatment with Bojungikgi-Tang and Riluzole Regulates Muscle Metabolism and Dysfunction in the hSOD1(G93A) Mouse Model
por: Cai, Mudan, et al.
Publicado: (2022)

Caudal–Rostral Progression of Alpha Motoneuron Degeneration in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Kirby, Alastair J., et al.
Publicado: (2022)

Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS
por: Kurlawala, Zimple, et al.
Publicado: (2023)

Extreme diversity of 12 cations in folding ALS-linked hSOD1 unveils novel hSOD1-dependent mechanisms for Fe(2+)/Cu(2+)-induced cytotoxicity
por: Lim, Liangzhong, et al.
Publicado: (2023)

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Song, Lin, et al.
Publicado: (2014)

Endothelin-1, over-expressed in SOD1(G93A) mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis
por: Zhang, Yingzhen, et al.
Publicado: (2022)

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1(G93A) mice
por: Scaricamazza, Silvia, et al.
Publicado: (2022)

NU-9 improves health of hSOD1(G93A) mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
por: Genç, Barış, et al.
Publicado: (2022)

The 2-Oxoglutarate Carrier Is S-Nitrosylated in the Spinal Cord of G93A Mutant hSOD1 Mice Resulting in Disruption of Mitochondrial Glutathione Transport
por: Linseman, Daniel A., et al.
Publicado: (2022)

A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1(G93A) model of ALS
por: Gerovska, Daniela, et al.
Publicado: (2023)

In-cell NMR in E. coli to Monitor Maturation Steps of hSOD1
por: Banci, Lucia, et al.
Publicado: (2011)

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
por: Banerjee, Rebecca, et al.
Publicado: (2008)

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Peters, Owen M, et al.
Publicado: (2018)

Retracted: Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: BioMed Research International,
Publicado: (2019)

Activation of the endoplasmic reticulum stress response in skeletal muscle of G93A*SOD1 amyotrophic lateral sclerosis mice
por: Chen, Dapeng, et al.
Publicado: (2015)

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype
por: Pinto, Sara, et al.
Publicado: (2017)

Treatment with Herbal Formula Extract in the hSOD1(G93A) Mouse Model Attenuates Muscle and Spinal Cord Dysfunction via Anti-Inflammation
por: Yang, Eun Jin, et al.
Publicado: (2022)

Neuroprotective Effect of Bexarotene in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Riancho, Javier, et al.
Publicado: (2015)

Comparing therapeutic modulators of the SOD1 G93A Amyotrophic Lateral Sclerosis mouse pathophysiology
por: Lee, Albert J. B., et al.
Publicado: (2023)

Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS
por: De Rose, Francescaelena, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k26aq73e5rs70uj72o64lpu5gi