Grb2 binding induces phosphorylation-independent activation of Shp2

The regulation of phosphatase activity is fundamental to the control of intracellular signalling and in particular the tyrosine kinase-mediated mitogen-activated protein kinase (MAPK) pathway. Shp2 is a ubiquitously expressed protein tyrosine phosphatase and its kinase-induced hyperactivity is assoc...

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Detalles Bibliográficos
Autores principales: Lin, Chi-Chuan, Wieteska, Lukasz, Suen, Kin Man, Kalverda, Arnout P., Ahmed, Zamal, Ladbury, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016844/
https://www.ncbi.nlm.nih.gov/pubmed/33795832
http://dx.doi.org/10.1038/s42003-021-01969-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016844/
https://www.ncbi.nlm.nih.gov/pubmed/33795832
http://dx.doi.org/10.1038/s42003-021-01969-7

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