Cargando…

Grb2 binding induces phosphorylation-independent activation of Shp2

The regulation of phosphatase activity is fundamental to the control of intracellular signalling and in particular the tyrosine kinase-mediated mitogen-activated protein kinase (MAPK) pathway. Shp2 is a ubiquitously expressed protein tyrosine phosphatase and its kinase-induced hyperactivity is assoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Chi-Chuan, Wieteska, Lukasz, Suen, Kin Man, Kalverda, Arnout P., Ahmed, Zamal, Ladbury, John E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016844/ https://www.ncbi.nlm.nih.gov/pubmed/33795832 http://dx.doi.org/10.1038/s42003-021-01969-7

Ejemplares similares

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Regulation of microRNA expression by the adaptor protein GRB2
por: Stainthorp, Amy K., et al.
Publicado: (2023)

The combined action of the intracellular regions regulates FGFR2 kinase activity
por: Lin, Chi-Chuan, et al.
Publicado: (2023)

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
por: Ahmed, Zamal, et al.
Publicado: (2015)

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
por: Ahmed, Zamal, et al.
Publicado: (2015)

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling
por: Lin, Chi-Chuan, et al.
Publicado: (2019)

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
por: Seiler, Caroline, et al.
Publicado: (2022)

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses
por: Schaeper, Ute, et al.
Publicado: (2000)

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
por: Lin, Chi-Chuan, et al.
Publicado: (2022)

Tyrosine phosphorylation of Grb14 by Tie2
por: Sturk, Celina, et al.
Publicado: (2010)

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
por: Choi, Seeyoung, et al.
Publicado: (2023)

GRB2 enforces homology-directed repair initiation by MRE11
por: Ye, Zu, et al.
Publicado: (2021)

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca(2+)(i) signal in B cells
por: Chen, Jie, et al.
Publicado: (2016)

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
por: Bongartz, Hannes, et al.
Publicado: (2019)

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
por: Franciosa, Giulia, et al.
Publicado: (2023)

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development
por: Clark, James F, et al.
Publicado: (2023)

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development
por: Clark, James F., et al.
Publicado: (2023)

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb2-SOS1-Grb2
por: Nag, Ambarish, et al.
Publicado: (2012)

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
por: Pfeiffer, Anamarija, et al.
Publicado: (2022)

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors
por: Xu, Xiaozheng, et al.
Publicado: (2021)

The Macronova in GRB 050709 and the GRB-macronova connection
por: Jin, Zhi-Ping, et al.
Publicado: (2016)

Novel Nonphosphorylated Peptides with Conserved Sequences Selectively Bind to Grb7 SH2 Domain with Affinity Comparable to Its Phosphorylated Ligand
por: Zhang, Dan, et al.
Publicado: (2012)

Structural and functional properties of Grb2 SH2 dimer in CD28 binding
por: Hosoe, Yuhi, et al.
Publicado: (2019)

TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways
por: Wang, Li-Na, et al.
Publicado: (2022)

Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer
por: Lara, Olivia D., et al.
Publicado: (2020)

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1
por: Qu, Yingying, et al.
Publicado: (2014)

The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42
por: Tien, Sui-Chih, et al.
Publicado: (2016)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

GRB2-associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer
por: Qiao, Xiang-Rui, et al.
Publicado: (2020)

Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML
por: Zhao, Yuming, et al.
Publicado: (2023)

Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection
por: Deng, Haoyu, et al.
Publicado: (2017)

Expansion microscopy reveals subdomains in C. elegans germ granules
por: Suen, Kin M, et al.
Publicado: (2023)

Correction: Expansion microscopy reveals subdomains in C. elegans germ granules
por: Suen, Kin M, et al.
Publicado: (2023)

CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells
Publicado: (1996)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy
por: Ye, Meng, et al.
Publicado: (2021)

Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
por: Jopling, Chris, et al.
Publicado: (2007)

2nd Gamma-Ray Burst Workshop - GRB 2
por: Brainerd, J J, et al.
Publicado: (1994)

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2
por: Toto, Angelo, et al.
Publicado: (2017)

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers
por: Kozer, Noga, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7ep6bkk4tef1gvu1n7dr5bbbd8