Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

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We report the identification of three structurally diverse compounds – compound 4, GC376, and MAC-5576 – as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for des...

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Detalles Bibliográficos
Autores principales: Iketani, Sho, Forouhar, Farhad, Liu, Hengrui, Hong, Seo Jung, Lin, Fang-Yu, Nair, Manoj S., Zask, Arie, Huang, Yaoxing, Xing, Li, Stockwell, Brent R., Chavez, Alejandro, Ho, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016852/
https://www.ncbi.nlm.nih.gov/pubmed/33795671
http://dx.doi.org/10.1038/s41467-021-22362-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016852/
https://www.ncbi.nlm.nih.gov/pubmed/33795671
http://dx.doi.org/10.1038/s41467-021-22362-2

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